Senior Director, Toxicology Job at Disc Medicine, Massachusetts

  • Disc Medicine
  • Massachusetts

Job Description

Disc Medicine seeks an experienced Senior Director of Toxicology to lead nonclinical safety assessments and toxicology strategy across its hematology drug portfolio. The role combines technical expertise in preclinical safety evaluation with cross-functional leadership, spanning from early discovery through regulatory approval in a hybrid Massachusetts-based position.

Responsibilities

  • Design, execute, and interpret nonclinical safety studies across all development phases
  • Establish dose justifications and safe clinical doses using pharmacokinetic data
  • Oversee toxicology study budgets, timelines, and conduct site monitoring visits
  • Collaborate with clinical, technical, and discovery teams on safety strategy and data interpretation
  • Draft toxicology sections of regulatory documents for IND and market authorization submissions

Requirements

  • Ph.D. in toxicology with 10-14 years of pharmaceutical industry experience
  • Expertise in GLP toxicology, reproductive toxicology, carcinogenicity, and safety pharmacology studies
  • Knowledge of ICH, FDA, and EMA global toxicology guidelines
  • Experience planning IND-enabling and late-stage nonclinical toxicity studies
  • Proficiency writing nonclinical safety sections for regulatory submissions (IND, NDA, MAA)
  • Strong presentation and cross-functional communication abilities
  • Track record of scientific publications or conference presentations

Job Tags

Similar Jobs

The Gainey Agency

Remote Insurance Sales Representative | Flexible Schedule | Training Provided Job at The Gainey Agency

 ...individuals who want more control over their schedule, income, and future. As a Remote Insurance Sales Representative, you'll work from home, connect with clients virtually, and help families find insurance solutions that fit their needs. Whether you're experienced in... 

24 Seven Talent

Women’s/Missy Apparel Designer Job at 24 Seven Talent

Schedule: In-office five days per week, with potential flexibility to work from home one day per week after acclimation.Were seeking a talented Womens/Missy Designer to help create and execute compelling apparel collections from concept through final prototype. This...

AuraOne

Motion Graphics Artist Job at AuraOne

 ...About the role Motion Graphics Artist is a remote review track for evaluating AI outputs across motion graphics artist specialist operations workflows. Reviewers grade workflow correctness, policy adherence, and stakeholder fit; flag operational risk; and document the... 

Catholic Schools in the Archdiocese of New York

Admissions and Events Assistant Job at Catholic Schools in the Archdiocese of New York

 ...benefits.Dominican Academy is an equal employment opportunity employer committed to hiring staff of diverse backgrounds. The school promotes respect for individuals regardless of race, color, religion, national origin, sex, age, disability, or any other classification... 

R-2 Contractors

Utility Scale Field Quality Control Rep Job at R-2 Contractors

 ...Contractors, we don't simply place concretewe build infrastructure, develop leaders, strengthen teams, and create a culture that refuses to settle for anything less than excellence. Apply today and help us build what's next. R-2 Contractors is an Equal Opportunity...